The significance of Goodpasture antigen in hereditary nephritis
نویسندگان
چکیده
منابع مشابه
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
BACKGROUND In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by alloantibodies against the GBM, occurs after kidney transplantation...
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15 صفحه اولPathology of hereditary nephritis.
This report describes the renal pathology in three siblings with hereditary nephritis. All three cases showed combined features of chronic glomerulonephritis, pyelonephritis, and interstitial nephritis. Foam cells were seen in only one case. These findings support the contention of Krickstein, Gloor, and Balogh (1966) that the renal changes in hereditary nephritis are those of a mixed nephritis.
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متن کاملSequence analysis of the 'Goodpasture antigen' of mammals.
BACKGROUND Autoimmunity to the NC1 domain of the alpha3 chain of type IV collagen (alpha3(IV)NC1), the Goodpasture antigen, is the cause of spontaneous human antiglomerular basement membrane (anti-GBM) disease, and of anti-GBM nephritis in several animal models. METHODS We have derived amino acid sequences from alpha3(IV)NC1 for a number of mammalian species (monkey, sheep, pig, dog, rabbit, ...
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ژورنال
عنوان ژورنال: Srpski arhiv za celokupno lekarstvo
سال: 2008
ISSN: 0370-8179,2406-0895
DOI: 10.2298/sarh08s4282b